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This post was originally published on this site 中国上海、成都,美国波士顿、新泽西–(BUSINESS WIRE)–(美国商业资讯)–和铂医药(Harbour BioMed)与专注于创新药物研发的四川科伦博泰生物医药股份有限公司(“科伦博泰”)宣布开展全球战略合作,和铂医药将获得科伦博泰处于临床二期阶段的PD-L1抗体药物A167在全球(除大中华地区以外)的独家开发、生产和商业化许可。此项协议潜在价值超过3.5亿美元以及销售提成。同时,双方还就在全球范围内A167和其他药物的联合用药的开发达成协议;双方将许可对方在各自区域内非竞争性的、与A167联合用药的开发权利。 A167是科伦博泰开发的肿瘤免疫抗体候选药物,通过抑制PD-L1、激发患者自身的免疫系统攻击肿瘤细胞,可用于多种血液肿瘤、实体肿瘤的治疗。A167目前已在国内开展针对淋巴瘤和实体肿瘤的多项一期和二期临床试验。 “肿瘤免疫领域PD-L1抗体药物已经在诸多的临床试验中得到验证,成为制药公司在肿瘤领域的关键布局。我们非常高兴能与科伦博泰深度合作,获得A167在大中华区外全球开发和商业化的独家许可。”和铂医药创始人、董事长兼首席执行官王劲松博士表示,“探索免疫疗法(如PD-1/PD-L1单抗)与其他药物的组合,寻找适合特定肿瘤的更有效安全的联合治疗方案,是当前全球抗肿瘤药物研究的创新点和突破点。和铂医药正同步研发一系列与A167联用的创新药物,未来可在全球领域独立或合作开展A167的联合用药研究,为多种恶性肿瘤的治疗提供更优的用药选择方案。与科伦博泰的此项合作将加速和铂医药临床阶段产品线的全球化布局,是和铂医药创新与合作战略的重要组成。” “今年初,我们与和铂医药达成协议,基于和铂全球领先的抗体发现平台,共同发现、开发和商业化创新靶点的全人源抗体药物。双方正在开展针对肿瘤和自身免疫等重大疾病的多个靶点的早期抗体研发项目且进展顺利。”科伦博泰首席执行官薛彤彤博士表示,“我们非常高兴能与和铂医药建立临床阶段产品的战略合作。科伦博泰围绕肿瘤免疫治疗布局了一系列创新药物,A167是其中的一项重点项目。合作来自双方对彼此研发能力及经验的认可,和铂医药拥有丰富的全球临床研究经验,通过合作我们将加速推进基于A167的广泛的全球化临床开发特别是联合用药开发及商业化。我们对于此次合作充满期待。” 基于此项合作协议,科伦博泰将获得首付款,并在达到预先约定的临床开发、注册及商业化目标时获得相应的里程碑付款,总计超过3.5亿美元;此外还将获得产品上市后的净销售额分成。和铂医药将主导A167在中国以外地区的临床开发及商业化,以及生产和经营权。两家公司将共享各自所有相关的研究数据,以支持在各自领域单药和联合用药的临床和注册。 关于和铂医药 (Harbour BioMed) 和铂医药是一家全球化的生物制药公司,利用其拥有全球专利的两个全人源抗体转基因小鼠平台(Harbour Mice)研发针对肿瘤和免疫性疾病的创新疗法。和铂医药还通过与业务伙伴的多元化合作快速拓展其新药研发管线。同时,和铂医药通过其全资子公司Harbour Antibodies BV向全球生物制药公司和学术机构授权其专利技术平台用于多种抗体新药研发。更多信息,请访问 www.harbourbiomed.com 关于科伦博泰(Kelun-Biotech) 四川科伦博泰生物医药股份有限公司是四川科伦药业股份有限公司的子公司,致力于生物大分子药物及创新小分子药物的研发、上市及国际合作,旨在为患者和医护人员提供更优的用药选择,从而提高人类的健康水平及生活质量。 公司重点开展恶性肿瘤、乙肝、代谢性疾病、自身免疫性疾病、麻醉、疼痛等国内外重大疾病领域的药物研究,目前已启动了20余项生物技术药物及30余项创新小分子药物的研究,其中5项生物技术药物正在开展临床研究;创新小分子药物4项处于临床阶段。更多信息,请访问 www.kelun-biotech.com Read more »

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